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Ubiquinol for egg quality

CoQ10 benefits for fertility, egg quality, and miscarriage prevention

Written by Jess Dyer

7 min-read
16citations
Ubiquinol for egg quality

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Research indicates that ubiquinol (the active form of Coenzyme Q10, or CoQ10) may improve egg and embryo quality and potentially reduce miscarriage rates. It's something I have prescribed countless times to women that are 35+ years old, doing IVF or have had recurrent miscarriages.

 

Here's a summary of the research:

 

1. Improved Egg Quality & Mitochondrial Function

  • CoQ10 supplementation was shown to enhance mitochondrial activity in oocytes, leading to improved egg quality.
  • The increased energy production in granulosa cells and oocytes contributes to healthier egg maturation.
  • Study Link

2. Reduction in Miscarriage Rates

  • Studies suggest that CoQ10's antioxidant properties may reduce oxidative stress, a factor linked to miscarriage and early embryo loss.
  • Though miscarriage rates were not significantly reduced in all trials, there was evidence of improved overall embryo quality, which could contribute to higher implantation rates.
  • Study Link

3. Use in IVF & Assisted Reproductive Technologies (ART)

  • CoQ10 has been used as an adjuvant therapy in ART, showing positive effects on egg quality and embryo development.
  • Supplementation at a dose of 200-600 mg/day was associated with improved mitochondrial function, better embryo grading, and increased clinical pregnancy rates.
  • Study Link

4. Ovarian Aging & CoQ10

  • CoQ10 supplementation helped prevent ovarian aging by maintaining oocyte mitochondrial health, leading to better outcomes in older women undergoing fertility treatments.
  • Long-term intake of CoQ10, particularly in women over 35, was linked to improved oocyte quality and increased chances of conception.
  • Study Link

5. Dosage Recommendations

  • Doses of 200-600 mg/day of ubiquinol are generally used in studies for improving fertility outcomes.
  • The dosage may vary based on individual needs, age, and specific fertility challenges. Consulting a healthcare provider is recommended for personalized guidance.

6. CoQ10 in Preventing Embryonic Loss

  • Research has shown that CoQ10 can support early embryonic development, increasing the likelihood of successful implantation and reducing early pregnancy loss.
  • The benefits are attributed to reduced oxidative stress and improved cellular energy metabolism in developing embryos.
  • Study Link

Summary

  • Ubiquinol (CoQ10) improves mitochondrial function, egg and embryo quality, and may reduce miscarriage risk, particularly in ART and older women.
  • Effective Dose: 200-600 mg/day is commonly used in fertility treatments.