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Research indicates that ubiquinol (the active form of Coenzyme Q10, or CoQ10) may improve egg and embryo quality and potentially reduce miscarriage rates. It's something I have prescribed countless times to women that are 35+ years old, doing IVF or have had recurrent miscarriages.
Here's a summary of the research:
1. Improved Egg Quality & Mitochondrial Function
- CoQ10 supplementation was shown to enhance mitochondrial activity in oocytes, leading to improved egg quality.
- The increased energy production in granulosa cells and oocytes contributes to healthier egg maturation.
- Study Link
2. Reduction in Miscarriage Rates
- Studies suggest that CoQ10's antioxidant properties may reduce oxidative stress, a factor linked to miscarriage and early embryo loss.
- Though miscarriage rates were not significantly reduced in all trials, there was evidence of improved overall embryo quality, which could contribute to higher implantation rates.
- Study Link
3. Use in IVF & Assisted Reproductive Technologies (ART)
- CoQ10 has been used as an adjuvant therapy in ART, showing positive effects on egg quality and embryo development.
- Supplementation at a dose of 200-600 mg/day was associated with improved mitochondrial function, better embryo grading, and increased clinical pregnancy rates.
- Study Link
4. Ovarian Aging & CoQ10
- CoQ10 supplementation helped prevent ovarian aging by maintaining oocyte mitochondrial health, leading to better outcomes in older women undergoing fertility treatments.
- Long-term intake of CoQ10, particularly in women over 35, was linked to improved oocyte quality and increased chances of conception.
- Study Link
5. Dosage Recommendations
- Doses of 200-600 mg/day of ubiquinol are generally used in studies for improving fertility outcomes.
- The dosage may vary based on individual needs, age, and specific fertility challenges. Consulting a healthcare provider is recommended for personalized guidance.
6. CoQ10 in Preventing Embryonic Loss
- Research has shown that CoQ10 can support early embryonic development, increasing the likelihood of successful implantation and reducing early pregnancy loss.
- The benefits are attributed to reduced oxidative stress and improved cellular energy metabolism in developing embryos.
- Study Link
Summary
- Ubiquinol (CoQ10) improves mitochondrial function, egg and embryo quality, and may reduce miscarriage risk, particularly in ART and older women.
- Effective Dose: 200-600 mg/day is commonly used in fertility treatments.
